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Chloramphenicol diffuses readily into milk, pleural and ascetic fluids and crosses the placenta. However, other USP experts still consider ophthalmic chloramphenicol valuable because of its lipid solubility and excellent corneal penetration, as well as its low ocular toxicity when compared with other antibacterials commonly used in the eye (e. Administration of chloramphenicol to dogs up to 24 days prior to anesthesia with sodium pentobarbital has been reported to result in prolonged anesthesia. Raramente, el uso prolongado de medicamentos de chloramphenicol han daсado la mйdula уsea. After using chloramphenicol eye ointment, wipe the tip of the ointment tube with a clean tissue and keep the tube tightly closed. Chloramphenicol should be used with extreme caution during full-term pregnancy and labor because the fetus may experience severe side effects.
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